Cattell V, Jamieson S W
J Pathol. 1975 Mar;115(3):183-9. doi: 10.1002/path.1711150309.
The morphological changes occurring in xenograft hyperacute rejection, using guinea-pig to rat cardiac transplants, have been studied. Ultrastructural evidence of platelet aggregation in myocardial capillaries and veins first occurred two minutes after revascularisation. Small amounts of fibrin, associated with platelet degranulation occurred at three minutes. From four minutes, platelet aggregates increased in number and endothelial damage first appeared in those vessels containing platelet aggregates. Rejection was complete by 12 minutes and platelet aggregates then filled many capillaries, veins, arterioles and arteries. Polymorphonuclear leucocyte infiltration was not seen.
利用豚鼠到大鼠的心脏移植，对异种移植超急性排斥反应中发生的形态学变化进行了研究。心肌毛细血管和静脉中血小板聚集的超微结构证据在血管再通后两分钟首次出现。三分钟时出现与血小板脱颗粒相关的少量纤维蛋白。从四分钟起，血小板聚集体数量增加，内皮损伤首先出现在含有血小板聚集体的血管中。12分钟时排斥反应完成，此时血小板聚集体充满了许多毛细血管、静脉、小动脉和动脉。未见多形核白细胞浸润。
