FC43乳剂对啮齿类动物非协调性异种移植中超急性排斥反应的影响。
Effects of FC43 emulsion against hyperacute rejection in rodent discordant xenotransplantation.
作者信息
Wada S, Kajihara H, Murakami H, Sueda T, Matsuura Y
机构信息
First Department of Surgery, Hiroshima University, School of Medicine, Japan.
出版信息
J Heart Lung Transplant. 1995 Sep-Oct;14(5):968-72.
BACKGROUND
FC43 emulsion is one of several perfluorochemical-based artificial blood compounds developed as a red blood cell substitute. However, these compounds are not promising as red blood cell substitutes because of their immunosuppressive effects. Therefore we used FC43 emulsion as an immunosuppressive agent and not as a red blood cell substitute.
METHODS
We assessed the effect of FC43 emulsion treatment on the survival of the grafted hearts in guinea pig-to-rat discordant transplantations.
RESULTS
In rats treated with FC43 emulsion (5 microliters/gm body weight), rhythmic beating of the heart was maintained for 433.3 +/- 40.0 minutes, whereas the untreated heartbeat lasted for only 15.3 +/- 5.1 minutes. In the xenografted hearts treated with FC43 emulsion, no pathologic changes such as multiple coronary thromboses caused by hyperacute rejection had occurred by 300 minutes after reperfusion.
CONCLUSIONS
FC43 emulsion can prolong the survival time of guinea pig heart xenografts by inhibiting thrombus formation in the xenografted heart.
背景
FC43乳剂是开发用作红细胞替代物的几种基于全氟化合物的人造血液化合物之一。然而，由于这些化合物的免疫抑制作用，它们作为红细胞替代物前景不佳。因此，我们将FC43乳剂用作免疫抑制剂而非红细胞替代物。
方法
我们评估了FC43乳剂处理对豚鼠到大鼠异种移植中移植心脏存活的影响。
结果
在用FC43乳剂（5微升/克体重）处理的大鼠中，心脏有节律的跳动维持了433.3±40.0分钟，而未处理的心脏跳动仅持续了15.3±5.1分钟。在用FC43乳剂处理的异种移植心脏中，再灌注后300分钟时未发生诸如由超急性排斥引起的多发性冠状动脉血栓形成等病理变化。
结论
FC43乳剂可通过抑制异种移植心脏中的血栓形成来延长豚鼠心脏异种移植的存活时间。
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