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巨大角膜及结膜鳞状细胞癌。

Massive corneal and conjunctival squamous cell carcinoma.

作者信息

Panda A, Sharma N, Sen S

机构信息

Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

出版信息

Ophthalmic Surg Lasers. 2000 Jan-Feb;31(1):71-2.

PMID:10976567
Abstract

A patient with massive, protuberant squamous cell carcinoma of conjunctiva invading the whole cornea, so as to hang from the surface, was referred with a visual acuity of hand motion near to face. A microscopically-controlled, frozen section guided excision, followed by double-freeze-thaw cryoapplication to the sclera and the edges of the conjunctival bed and lamello-lamellar sclerokeratoplasty, was performed. Three years later the patient's visual acuity was 20/60 with no evidence of recurrence of the lesion. Frozen section guided excision with adjuvant cryotherapy and lamellar sclerokeratoplasty is a viable therapy for massive squamous cell carcinoma of cornea and conjunctiva.

摘要

一名患有巨大、突出的结膜鳞状细胞癌的患者,癌组织侵犯整个角膜,以至于从角膜表面垂挂下来,转诊时其视力为眼前手动。实施了在显微镜控制下的冰冻切片引导切除,随后对巩膜和结膜床边缘进行双重冻融冷冻治疗以及板层-板层巩膜角膜移植术。三年后,患者视力为20/60,病变无复发迹象。冰冻切片引导切除联合辅助冷冻治疗及板层巩膜角膜移植术是治疗大面积角膜和结膜鳞状细胞癌的一种可行疗法。

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Ocul Oncol Pathol. 2018 Jun;4(4):240-249. doi: 10.1159/000485425. Epub 2018 Jan 19.
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Ocular surface squamous neoplasia - Review of etio-pathogenesis and an update on clinico-pathological diagnosis.眼表鳞状上皮肿瘤——病因发病机制综述及临床病理诊断新进展
Saudi J Ophthalmol. 2013 Jul;27(3):177-86. doi: 10.1016/j.sjopt.2013.07.002.
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Corneal cell viability and structure after transcorneal freezing-thawing in the human cornea.
人眼角膜经角膜冻融后的细胞活力与结构
Clin Ophthalmol. 2010 May 25;4:477-80. doi: 10.2147/opth.s9880.
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"Finger-tip" cryotherapy probes: treatment of squamous and melanocytic conjunctival neoplasia.“指尖”冷冻治疗探头:结膜鳞状和黑素细胞性肿瘤的治疗
Br J Ophthalmol. 2005 Aug;89(8):942-5. doi: 10.1136/bjo.2004.064204.
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Squamous cell carcinoma of the conjunctiva.结膜鳞状细胞癌
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Amniotic membrane transplantation.羊膜移植
Br J Ophthalmol. 2002 Dec;86(12):1460. doi: 10.1136/bjo.86.12.1460.