Ahn C M, Tak J A, Choi S J
Department of Basic Sciences, Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Korea.
Arch Pharm Res. 2000 Aug;23(4):288-301. doi: 10.1007/BF02975437.
A series of 2-alkyl, 2-aryl, and 2-piperazinyl benzimidazole-4,7-dione derivatives (7a-h) and 16m-o) were prepared, and their cytotoxicities were tested against three cancer cell lines (mouse lymphocytic leukemia cell line P388, and human gastric carcinoma cell lines SNU-1 and SNU-16). These compounds showed potent cytotoxicity against all of three cell lines tested, and especially SNU-16 was sensitive to them. 2-Aryl (7g,h) and 2-piperazinyl benzimidazole-4,7-dione derivative (16 m) were more potent than mitomycin C against P388 and SNU-16. Among benzimidazole-4,7-dione derivatives with alkyl group at position 2, 7a had the most potent cytotoxicity against all of the cell lines tested.
制备了一系列2-烷基、2-芳基和2-哌嗪基苯并咪唑-4,7-二酮衍生物（7a-h）和16m-o），并测试了它们对三种癌细胞系（小鼠淋巴细胞白血病细胞系P388以及人胃癌细胞系SNU-1和SNU-16）的细胞毒性。这些化合物对所有测试的三种细胞系均显示出强效细胞毒性，尤其是SNU-16对它们敏感。2-芳基（7g，h）和2-哌嗪基苯并咪唑-4,7-二酮衍生物（16m）对P388和SNU-16的活性比丝裂霉素C更强。在2位带有烷基的苯并咪唑-4,7-二酮衍生物中，7a对所有测试细胞系的细胞毒性最强。
