SNU 细胞系的生物学特性。
Biology of SNU cell lines.
机构信息
Korean Cell Line Bank, Laboratory of Cell Biology, Cancer Research Center and Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
出版信息
Cancer Res Treat. 2005 Feb;37(1):1-19. doi: 10.4143/crt.2005.37.1.1. Epub 2005 Feb 28.
Abstract
SNU (Seoul National University) cell lines have been established from Korean cancer patients since 1982. Of these 109 cell lines have been characterized and reported, i.e., 17 colorectal carcinoma, 12 hepatocellular carcinoma, 11 gastric carcinoma, 12 uterine cervical carcinoma, 17 B-lymphoblastoid cell lines derived from cancer patients, 5 ovarian carcinoma, 3 malignant mixed Mllerian tumor, 6 laryngeal squamous cell carcinoma, 7 renal cell carcinoma, 9 brain tumor, 6 biliary tract, and 4 pancreatic carcinoma cell lines. These SNU cell lines have been distributed to biomedical researchers domestic and worldwide through the KCLB (Korean Cell Line Bank), and have proven to be of value in various scientific research fields. The characteristics of these cell lines have been reported in over 180 international journals by our laboratory and by many other researchers from 1987. In this paper, the cellular and molecular characteristics of SNU human cancer cell lines are summarized according to their genetic and epigenetic alterations and functional analysis.
摘要
SNU（首尔国立大学）细胞系自 1982 年以来一直从韩国癌症患者中建立。其中 109 种细胞系已被鉴定和报道，即 17 种结直肠癌、12 种肝细胞癌、11 种胃癌、12 种宫颈癌、17 种源自癌症患者的 B 淋巴细胞母细胞系、5 种卵巢癌、3 种恶性混合 Müller 瘤、6 种喉鳞状细胞癌、7 种肾细胞癌、9 种脑肿瘤、6 种胆道和 4 种胰腺癌细胞系。这些 SNU 细胞系通过 KCLB（韩国细胞系库）分发给国内外的生物医学研究人员，并已证明在各个科学研究领域具有价值。自 1987 年以来，我们实验室和许多其他研究人员已在 180 多种国际期刊上报道了这些细胞系的特征。在本文中，根据遗传和表观遗传改变以及功能分析，总结了 SNU 人癌细胞系的细胞和分子特征。
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