作为潜在抗病毒剂的（-）-奈拉米星A类似物的合成。
Synthesis of (-)-neplanocin A analogues as potential antiviral agents.
作者信息
Shin D H, Lee H W, Park S S, Kim J H, Jeong L S, Chun M W
机构信息
College of Pharmacy, Seoul National University, Korea.
出版信息
Arch Pharm Res. 2000 Aug;23(4):302-9. doi: 10.1007/BF02975438.
PMID:10976574
Abstract
Based on (-)-neplanocin A with the 5'-hydroxyl substituted with fluoro, azido, or amino group, the corresponding xylo- and arabino derivatives were synthesized from D-ribose using the Mitsunobu reaction as a key step. None of the final nucleosides did show either significant antiviral activities or cytotoxicities.
摘要
基于5'-羟基被氟、叠氮基或氨基取代的(-)-奈拉滨A，以Mitsunobu反应为关键步骤，从D-核糖合成了相应的木糖型和阿拉伯糖型衍生物。最终的核苷均未显示出显著的抗病毒活性或细胞毒性。
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