新型开链奈拉滨类似物的合成与抗病毒活性评价
Synthesis and antiviral evaluation of novel open-chain analogues of neplanocin A.
作者信息
Hong Joon Hee, Kim So-Young, Oh Chang-Hyun, Yoo Kyung Ho, Cho Jung-Hyuck
机构信息
Medicinal Chemistry Research Center, Korea Institute of Science and Technology, Seoul, Korea.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2006 Mar;25(3):341-50. doi: 10.1080/15257770500544578.
PMID:16629127
Abstract
Novel acyclic nucleoside analogues were designed and synthesized as open-chain analogues of neplanocin A. The coupling of the allylic bromide with purine bases using cesium carbonate afforded a series of novel acyclic nucleosides. The synthesized compounds Ia-II were evaluated for their antiviral activity against various viruses such as HIV HSV-1, HSV-2, and ECMV.
摘要
新型无环核苷类似物被设计并合成为奈拉滨的开链类似物。使用碳酸铯使烯丙基溴与嘌呤碱偶联，得到了一系列新型无环核苷。对合成的化合物Ia-II针对多种病毒（如HIV、HSV-1、HSV-2和ECMV）的抗病毒活性进行了评估。
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