New neplanocin analogues. IV. 2-Fluoroneplanocin A: an adenosine deaminase-resistant equivalent of neplanocin A.
作者信息
Shuto S, Obara T, Itoh H, Kosugi Y, Saito Y, Toriya M, Yaginuma S, Shigeta S, Matsuda A
机构信息
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1994 Aug;42(8):1688-90. doi: 10.1248/cpb.42.1688.
PMID:7954923
Abstract
2-Fluoro- and 2-chloroneplanocin A's (2 and 3) were synthesized as an adenosine deaminase resistant-equivalent of neplanocin A, and evaluated for their antitumor and antiviral activities. Of these, 2 was completely resistant to adenosine deaminase and showed more significant antitumor and antiviral activities than neplanocin A.
摘要
Zotero 插件