Gene polymorphism affecting alpha1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk.

作者信息

Licastro F, Pedrini S, Ferri C, Casadei V, Govoni M, Pession A, Sciacca F L, Veglia F, Annoni G, Bonafè M, Olivieri F, Franceschi C, Grimaldi L M

机构信息

Dipartimento di Patologia Sperimentale, School of Medicine, University of Bologna, Italy.

出版信息

Ann Neurol. 2000 Sep;48(3):388-91.

Plasma levels of alpha1-antichymotrypsin (ACT) and interleukin-1beta (IL-1beta) were increased in patients with probable Alzheimer's disease (AD). A common polymorphism within ACT and IL-1beta genes affected plasma levels of ACT or IL-1beta, and AD patients with the ACT T,T or IL-1beta T,T genotype showed the highest levels of plasma ACT or IL-1beta, respectively. The concomitant presence of the ACT T,T and IL-1beta T,T genotypes increased the risk of AD (odds ratio: 5.606, confidence interval: 1.654-18.996) and decreased the age at onset of the disease.