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C57BL/6和BALB/c小鼠单胺代谢差异的多维评估

Multidimensional assessment of differences in monoamine metabolism in C57BL/6 and BALB/c mice.

作者信息

Seredenin S B, Lapitskaya A S, Nadorov S A, Kudrin V S, Badyshtov B A

机构信息

Department of Molecular Genetics, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.

出版信息

Bull Exp Biol Med. 2000 May;129(5):487-90. doi: 10.1007/BF02439811.

DOI:10.1007/BF02439811
PMID:10977960
Abstract

Monoamine metabolism in the hypothalamus and striatum of BALB/c and C57Bl/6 mice (intact and stressed in the open field test) was studied using single- and multidimensional statistical methods. It is suggested that the revealed difference in neurotransmitter metabolism is associated with genetically controlled behavior of these animals under conditions of emotional stress. The results of discriminant analysis suggest that the regulation of monoamine metabolism during emotional stress is genetically determined.

摘要

使用单维和多维统计方法研究了BALB/c和C57Bl/6小鼠(在旷场试验中未处理和应激状态下)下丘脑和纹状体中的单胺代谢。研究表明,所揭示的神经递质代谢差异与这些动物在情绪应激条件下的遗传控制行为有关。判别分析结果表明,情绪应激期间单胺代谢的调节是由基因决定的。

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