Narkevich V B, Kudrin V S, Klodt P M, Pokrovskiĭ A A, Kozlovskaia M M, Maĭskiĭ A I, Raevskiĭ K S
Eksp Klin Farmakol. 2008 Sep-Oct;71(5):8-12.
The effect of heptapeptide selank on the content of neurotransmitter monoamines and its metabolites in the brain structures of BALB/C and C57Bl/6 line mice under conditions of the open-field test were studied. Significant interstrain differences in the content of norepinephrine (NE), dopamine (DA), serotonin (5-HT) as well as in the levels of their metabolites in hippocampus, hypothalamus, striatum and frontal cortex of C57Bl/6 and BALB/C mice were demonstrated. In particular, the content of 5-HT and its metabolite 5-oxyindolacetic acid (5-HIAA) in hippocampus of BALB/C mice (with passive stress response) was higher than in the same structure of C57Bl/6 (stress-susceptible) animals. The injection of selank (0.3 mg/kg) led to an increase in the NE level in the hypothalamus of both mice strains. At the same time, selank produced opposite effects on the content of DA metabolites: the concentrations of dioxyphenylacetic (DOPAC) and homovanillic (HVA) acids were found to increase in frontal cortex and hippocampus of C57Bl/6 mice, while the same parameters in BALB/C mice were demonstrated to decrease. Selank induced a decrease in 5-HT and 5-HIAA levels in the hippocampus of BALB/C mice, but did not affect these parameters in C57Bl/6 animals. The obtained results are indicative of selectivity of the anxiolytic effects of selank.
研究了七肽塞兰在旷场试验条件下对BALB/C和C57Bl/6系小鼠脑结构中神经递质单胺及其代谢产物含量的影响。结果表明，C57Bl/6和BALB/C小鼠海马、下丘脑、纹状体和额叶皮质中去甲肾上腺素（NE）、多巴胺（DA）、5-羟色胺（5-HT）的含量及其代谢产物水平存在显著的品系间差异。特别是，BALB/C小鼠（具有被动应激反应）海马中5-HT及其代谢产物5-羟吲哚乙酸（5-HIAA）的含量高于C57Bl/6（应激易感）动物相同脑区。注射塞兰（0.3mg/kg）使两种品系小鼠下丘脑NE水平升高。同时，塞兰对DA代谢产物含量产生相反的影响：C57Bl/6小鼠额叶皮质和海马中3,4-二羟基苯乙酸（DOPAC）和高香草酸（HVA）的浓度升高，而BALB/C小鼠的相同参数则降低。塞兰使BALB/C小鼠海马中5-HT和5-HIAA水平降低，但对C57Bl/6动物这些参数无影响。所得结果表明塞兰抗焦虑作用具有选择性。
