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适度饮酒与老年人的生存率相关:达博研究。

Moderate alcohol intake is associated with survival in the elderly: the Dubbo Study.

作者信息

Simons L A, McCallum J, Friedlander Y, Ortiz M, Simons J

机构信息

University of New South Wales Lipid Research Department, St Vincent's Hospital, Sydney, NSW.

出版信息

Med J Aust. 2000 Aug 7;173(3):121-4. doi: 10.5694/j.1326-5377.2000.tb125562.x.

Abstract

OBJECTIVE

To examine the relationship between alcohol intake and survival in elderly people.

DESIGN AND SETTING

A prospective study over 116 months of non-institutionalised subjects living in Dubbo, a rural town (population, 34,000) in New South Wales.

PARTICIPANTS

1235 men and 1570 women aged 60 years and over who were first examined in 1988-89.

MAIN OUTCOME MEASURES

All-causes mortality; gross cost of alcohol per life-year gained.

RESULTS

Death occurred in 450 men and 392 women. Intake of alcohol was generally moderate (i.e., less than 14 drinks/week). Any intake of alcohol was associated with reduced mortality in men up to 75 years and in women over 64 years. In a proportional hazards model, the hazard ratio for mortality in men taking any alcohol was 0.63 (95% CI, 0.47-0.84) and in women was 0.75 (95% CI, 0.60-0.94). Cardiovascular deaths in men were reduced from 20/100 (95% CI, 14-26) to 11/100 (95% CI, 9-13) and in women from 16/100 (95% CI, 13-19) to 8/100 (95% CI, 6-10). The reduction in mortality occurred in men and women taking only 1-7 drinks/week--hazard ratios, 0.68 (95% CI, 0.49-0.94) and 0.78 (95% CI, 0.61-0.99), respectively, with a similar protective effect from intake of beer or other forms of alcohol. After almost 10 years' follow-up, men taking any alcohol lived on average 7.6 months longer, and women on average 2.7 months longer, compared with non-drinkers. The gross cost for alcohol per life-year gained if consuming 1-7 drinks/week was $5700 in men, and $19,000 in women.

CONCLUSIONS

Moderate alcohol intake in the elderly appears to be associated with significantly longer survival in men 60-74 years and in all elderly women.

摘要

目的

研究老年人饮酒量与生存率之间的关系。

设计与背景

对新南威尔士州一个乡村小镇(人口34,000)达博的116个月的非机构化受试者进行前瞻性研究。

参与者

1988 - 1989年首次接受检查的1235名男性和1570名60岁及以上的女性。

主要观察指标

全因死亡率;每获得一个生命年的酒精总成本。

结果

450名男性和392名女性死亡。饮酒量一般适中(即每周少于14杯)。任何饮酒量都与75岁以下男性和64岁以上女性的死亡率降低有关。在比例风险模型中,饮酒男性的死亡风险比为0.63(95%可信区间,0.47 - 0.84),女性为0.75(95%可信区间,0.60 - 0.94)。男性心血管疾病死亡率从20/100(95%可信区间,14 - 26)降至11/100(95%可信区间,9 - 13),女性从16/100(95%可信区间,13 - 19)降至8/100(95%可信区间,6 - 10)。仅每周饮用1 - 7杯酒的男性和女性死亡率降低——风险比分别为0.68(95%可信区间,0.49 - 0.94)和0.78(95%可信区间,0.61 - 0.99),饮用啤酒或其他形式的酒精具有类似的保护作用。经过近10年的随访,与不饮酒者相比,饮酒男性平均多活7.6个月,女性平均多活2.7个月。如果每周饮用1 - 7杯酒,男性每获得一个生命年的酒精总成本为5700美元,女性为19,000美元。

结论

老年人适度饮酒似乎与60 - 74岁男性和所有老年女性的显著更长生存期相关。

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