Simons L A, McCallum J, Friedlander Y, Simons J
University of New South Wales Lipid Research Department, St. Vincent's Hospital, Sydney.
Aust N Z J Med. 1996 Oct;26(5):662-70. doi: 10.1111/j.1445-5994.1996.tb02937.x.
A prospective study in non-institutionalised Australian elderly aged 60 years and over commenced in Dubbo, NSW in 1988.
To examine the relationship between all-causes mortality and alcohol intake.
The data were derived from a community-based sample comprising 1236 men and 1569 women followed for a median period of 77 months. Regular alcohol intake was reported by 78% of men and 52% of women. Eighty-seven per cent of men and 44% of women primarily drank beer.
Death occurred in 305 men and 236 women, 34% and 39% respectively from coronary heart disease (CHD). In a proportional hazards model, the hazard ratio (HR) for all-causes mortality in male drinkers, compared with abstainers, was 0.75 at one-seven drinks/week, 0.76 at eight-14 drinks/week, 0.69 at 15-28 drinks/week and 0.49 at > 28 drinks/week (p < 0.04), an inverse relationship. In female drinkers, HR was 0.78 at one-seven drinks/week, 0.49 at eight-14 drinks/week (p < 0.04) and 0.62 at 15-28 drinks/weeks, potentially a U shaped relationship. The effect on all-causes mortality could not be attributed to a differential effect of beer versus wine/spirit intake. Although the mortality rate was lower in those taking any alcohol compared with abstainers, those taking any alcohol exhibited an increased proportion of deaths due to cancer at the expense of a reduced proportion of CHD and stroke deaths.
Alcohol intake in the Dubbo elderly appears to be independently associated with a significant increase in life expectancy. Mechanisms underlying the effect may emerge at a longer interval of follow-up.
1988年在新南威尔士州的达博开始了一项针对60岁及以上非机构化澳大利亚老年人的前瞻性研究。
研究全因死亡率与酒精摄入量之间的关系。
数据来自一个基于社区的样本,包括1236名男性和1569名女性,随访中位时间为77个月。78%的男性和52%的女性报告有规律饮酒。87%的男性和44%的女性主要饮用啤酒。
305名男性和236名女性死亡,分别有34%和39%死于冠心病(CHD)。在比例风险模型中,与戒酒者相比,男性饮酒者全因死亡率的风险比(HR)在每周饮用1至7杯时为0.75,每周饮用8至14杯时为0.76,每周饮用15至28杯时为0.69,每周饮用超过28杯时为0.49(p<0.04),呈负相关。在女性饮酒者中,HR在每周饮用1至7杯时为0.78,每周饮用8至14杯时为0.49(p<0.04),每周饮用15至28杯时为0.62,可能呈U形关系。对全因死亡率的影响不能归因于啤酒与葡萄酒/烈酒摄入量的差异效应。尽管与戒酒者相比,饮酒者的死亡率较低,但饮酒者因癌症导致的死亡比例增加,而冠心病和中风死亡比例降低。
达博老年人的酒精摄入似乎与预期寿命显著增加独立相关。这种影响的潜在机制可能在更长的随访期后显现。