Shaiakhmetova H M, Kovalenko V M, Bondarenko L B, Kuz'menko I V
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
Ukr Biokhim Zh (1999). 2000 Mar-Apr;72(2):61-7.
In the experiments in vivo on white rats possibility of paracetamol hepatotoxic effects correction with synthetic short-chain alpha-tocopherol derivative and pharmacopeial preparation of vitamin E has been studied. Levels of superoxide anion generation in liver mitochondria fraction, catalase activity and reduced glutathione, serum aminotransferase and alcaline phosphatase activities and liver subcellular fractions lipid contents were investigated. It was shown that the short-chain vitamin E derivative and pharmacopeial preparation had a membranotropic effect, normalizing free and total cholesterol levels in liver mitochondria fraction and decreasing serum aminotransferase activity level. Investigated compounds also decreased levels of superoxide anions generation, increased catalase activity and level of reduced glutathione in liver. Antioxidative properties of this derivative and pharmacopeial preparation were demonstrated both at the primary (dienes, trienes) and at final steps of lipid peroxidation (TBA-products formation). This antioxidative activity of alpha-tocopherol acetate and its derivative depended on the structure of chromane cycle but not on the length of side chain.
在对白鼠进行的体内实验中，研究了用合成短链α-生育酚衍生物和维生素E的药典制剂纠正扑热息痛肝毒性作用的可能性。研究了肝线粒体部分中超氧阴离子生成水平、过氧化氢酶活性和还原型谷胱甘肽、血清氨基转移酶和碱性磷酸酶活性以及肝亚细胞部分的脂质含量。结果表明，短链维生素E衍生物和药典制剂具有膜趋向性作用，可使肝线粒体部分的游离胆固醇和总胆固醇水平正常化，并降低血清氨基转移酶活性水平。所研究的化合物还降低了超氧阴离子生成水平，增加了肝脏中过氧化氢酶活性和还原型谷胱甘肽水平。该衍生物和药典制剂的抗氧化特性在脂质过氧化的初级阶段（二烯、三烯）和最终阶段（TBA产物形成）均得到了证实。α-生育酚醋酸酯及其衍生物的这种抗氧化活性取决于色满环的结构，而不取决于侧链的长度。
