Aguayo A, Kantarjian H, Manshouri T, Gidel C, Estey E, Thomas D, Koller C, Estrov Z, O'Brien S, Keating M, Freireich E, Albitar M
Departments of Leukemia, Hematopathology, and Bioimmunotherapy, University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030-4095, USA.
Blood. 2000 Sep 15;96(6):2240-5.
Angiogenesis has been associated with the growth, dissemination, and metastasis of solid tumors. The aims of this study were to evaluate the vascularity and the levels of angiogenic factors in patients with acute and chronic leukemias and myelodysplastic syndromes (MDS). The numbers of blood vessels were measured in 145 bone marrow biopsies and the levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis growth factor-alpha (TNF-alpha), tumor growth factor-alpha (TGF-alpha), and hepatocyte growth factor (HGF) were determined in 417 plasma samples. Except for chronic lymphocytic leukemia (CLL), vascularity was significantly higher in all leukemias and MDS compared with control bone marrows. The highest number of blood vessels and largest vascular area were found in chronic myeloid leukemia (CML). VEGF, bFGF, and HGF plasma levels were significantly increased in acute myeloid leukemia (AML), CML, CLL, chronic myelomonocytic leukemia (CMML), and MDS. HGF, TNF-alpha, and bFGF but not VEGF were significantly increased in acute lymphoblastic leukemia (ALL). TNF-alpha levels were significantly increased in all diseases except for AML and MDS. No significant increase was found in TGF-alpha in any leukemia or MDS. The highest plasma levels of VEGF were in CML, and the highest plasma levels of bFGF were in CLL. The levels of HGF were highest in CMML. These data suggest that vascularity and angiogenic factors are increased in leukemias and MDS and may play a role in the leukemogenic process.
血管生成与实体瘤的生长、扩散及转移相关。本研究旨在评估急性和慢性白血病以及骨髓增生异常综合征（MDS）患者的血管生成情况及血管生成因子水平。在145份骨髓活检样本中测量血管数量，并在417份血浆样本中测定血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、肿瘤坏死因子-α（TNF-α）、肿瘤生长因子-α（TGF-α）和肝细胞生长因子（HGF）的水平。除慢性淋巴细胞白血病（CLL）外，所有白血病和MDS患者的血管生成情况与对照骨髓相比均显著增加。慢性髓性白血病（CML）的血管数量最多，血管面积最大。急性髓性白血病（AML）、CML、CLL、慢性粒单核细胞白血病（CMML）和MDS患者的VEGF、bFGF和HGF血浆水平显著升高。急性淋巴细胞白血病（ALL）患者的HGF、TNF-α和bFGF水平显著升高，但VEGF未升高。除AML和MDS外，所有疾病的TNF-α水平均显著升高。在任何白血病或MDS中，TGF-α均未显著升高。VEGF血浆水平最高的是CML，bFGF血浆水平最高的是CLL。CMML患者的HGF水平最高。这些数据表明，白血病和MDS患者的血管生成及血管生成因子增加，可能在白血病发生过程中起作用。
