Sorenson C A, Gordon M
Pharmacol Biochem Behav. 1975 May-Jun;3(3):331-5. doi: 10.1016/0091-3057(75)90039-8.
Tests of emotionality and shock-elicited aggression, which have revealed consistent changes in behavior in male rats given 6-hydroxydopamine (6-OHDA), were administered to female rats intraventricularly injected with 250 mug of 6-OHDA to determine whether aspects of the 6-OHDA syndrome are shared by female and male rats. The results confirmed that female rats become hyperemotional as well as hyperaggressive after 6-OHDA, as do males. Using the hypothesis that the behavioral effects of 6-OHDA lesions of catecholamine neurons result from a general reduction in threshold to aversive stimuli, it was predicted that arbitrarily selected stimuli having aversive components should enhance the behavior normally elicited by these stimuli. Stimuli selected for testing were those that normally elicit maternal defensive aggression and maternal retrieval. Both of these behaviors were found to be enhanced in 6-OHDA treated female rats, thus supporting the prediction. These findings were interpreted as inconsistent with the hypothesis that norepinephrine chemically codes specific behaviors, particularly aggressive behavior.
对经脑室内注射250微克6-羟基多巴胺（6-OHDA）的雌性大鼠进行了情绪和电击诱发攻击测试，这些测试已揭示了给予6-OHDA的雄性大鼠行为上的持续变化，以确定6-OHDA综合征的某些方面是否在雌性和雄性大鼠中都存在。结果证实，6-OHDA处理后的雌性大鼠与雄性大鼠一样，变得情绪过度激动且攻击性增强。基于儿茶酚胺神经元的6-OHDA损伤的行为效应是由对厌恶刺激的阈值普遍降低所致这一假设，预计任意选择的具有厌恶成分的刺激应会增强这些刺激通常引发的行为。选择用于测试的刺激是那些通常引发母性防御性攻击和母性找回行为的刺激。发现在经6-OHDA处理的雌性大鼠中，这两种行为均增强，从而支持了这一预测。这些发现被解释为与去甲肾上腺素以化学方式编码特定行为，尤其是攻击行为这一假设不一致。
