生殖生物学中的放射性配体分析

Radioligand assay in reproductive biology.

作者信息

Korenman S G, Sherman B M

出版信息

Semin Nucl Med. 1975 Jul;5(3):263-72. doi: 10.1016/s0001-2998(75)80014-6.

Abstract

Radioligand assays have been developed for the principal reproductive steroids and peptide hormones. Specific binding reagents have included antibodies, plasma binders, and intracellular receptors. In each assay, problems of specificity, sensitivity, and nonspecific inhibitors were encountered. Many features of the endocrine physiology in childhood, during puberty, and in adulthood have been characterized. Hormonal evaluations of endocrine disorders of reproduction are characterized on the basis of their characteristic pathophysiologic alterations.

摘要

已开发出针对主要生殖甾体和肽类激素的放射性配体测定法。特异性结合试剂包括抗体、血浆结合蛋白和细胞内受体。在每种测定法中，都遇到了特异性、敏感性和非特异性抑制剂方面的问题。儿童期、青春期和成年期内分泌生理学的许多特征已得到描述。生殖内分泌疾病的激素评估是根据其特征性病理生理改变来进行描述的。