Siegberg R, Nilsson C G, Stenman U H, Widholm O
Fertil Steril. 1984 Jun;41(6):888-93. doi: 10.1016/s0015-0282(16)47903-3.
The hormonal profiles and the effect of oral contraceptives (OCs) on 16 oligomenorrheic and 10 regularly menstruating adolescent girls were studied. Testosterone, androstenedione, dehydroepiandrosterone, estradiol, progesterone, luteinizing hormone, follicle-stimulating hormone, prolactin, and sex-hormone-binding globulin were determined on blood samples obtained during a control cycle, during OC treatment, and during the follow-up cycle after discontinuation of OC use. The oligomenorrheic girls had significantly higher concentrations of androstenedione and total and free testosterone than regularly menstruating girls during the control cycle. Sex-hormone-binding globulin concentrations were significantly lower in the oligomenorrheic group. Both in oligomenorrheic and regularly menstruating girls OC treatment caused a decrease in the mean concentrations of all hormones, except prolactin, to similar levels. For 2 to 4 weeks after treatment the oligomenorrheic girls had significantly lower levels of androstenedione, total and free testosterone, and luteinizing hormone than before treatment. In the control group there were no significant differences between pretreatment and posttreatment hormone concentrations. The risks and benefits of prescribing OCs for oligomenorrheic adolescent girls are discussed.
研究了口服避孕药（OCs）对16名月经过少的青春期女孩和10名月经正常的青春期女孩的激素水平及影响。在对照周期、OC治疗期间以及停用OC后的随访周期采集血样，测定睾酮、雄烯二酮、脱氢表雄酮、雌二醇、孕酮、黄体生成素、卵泡刺激素、催乳素和性激素结合球蛋白。在对照周期中，月经过少的女孩的雄烯二酮以及总睾酮和游离睾酮浓度显著高于月经正常的女孩。月经过少组的性激素结合球蛋白浓度显著较低。在月经过少和月经正常的女孩中，OC治疗均使除催乳素外的所有激素的平均浓度降低至相似水平。治疗后2至4周，月经过少的女孩的雄烯二酮、总睾酮和游离睾酮以及黄体生成素水平显著低于治疗前。在对照组中，治疗前和治疗后的激素浓度无显著差异。讨论了为月经过少的青春期女孩开OCs的风险和益处。
