3-芳基斯德酮的1,5-苯并二氮杂䓬衍生物：3-芳基-4-[2'-芳基-2',4',6',7'-四氢-(1'H)-1',5'-苯并二氮杂䓬-4'-基]斯德酮的合成与抗菌活性
1,5-benzodiazepine derivatives of 3-arylsydnones: synthesis and antimicrobial activity of 3-aryl-4-[2'-aryl-2',4',6',7'-tetrahydro-(1'H)-1',5'-benzodiazepine-4' -yl]sydnones.
作者信息
Kavali J R, Badami B V
机构信息
Post-graduate Department of studies in Chemistry, Karnatak University, Dharwad, India.
出版信息
Farmaco. 2000 May;55(5):406-9. doi: 10.1016/s0014-827x(00)00061-6.
Abstract
The alpha-beta-unsaturated ketones of 3-arylsydnones (Ia-y) were treated with 1,2-phenylenediamine to obtain the 3-aryl-4-[2'-aryl- 2',4',6',7'-tetrahydro-(1'H)-1',5'-benzodiazepine-4'-yl]sydnones (IIa-y) in high yield. All the new compounds synthesised were screened for antibacterial and antifungal activities.
摘要
将3-芳基斯德酮（Ia-y）的α-β-不饱和酮与1,2-苯二胺反应，以高收率得到3-芳基-4-[2'-芳基-2',4',6',7'-四氢-(1'H)-1',5'-苯并二氮杂䓬-4'-基]斯德酮（IIa-y）。对所有合成的新化合物进行了抗菌和抗真菌活性筛选。
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