Januszek-Trzciakowska A, Małecka-Tendera E, Lewin-Kowalik J
Kliniki Endokrynologii i Diabetologii Dzieciecej Slaskiej, Akademii Medycznej, Katowicach.
Wiad Lek. 2000;53(5-6):312-7.
Premature breast development (premature thelarche) is a common reason of referring prepubertal girls for endocrinological evaluation. It is considered as a benign condition but its pathogenesis is still unknown. It is postulated that it may be due to premature partial activation of hypothalamo-pituitary axis or to the increased sensitivity of breast tissue to normal, prepubertal estradiol levels. Although it rarely progresses to central precocious puberty the differential diagnostics is essential, as the latter pathology should be treated as early as possible. So called "exaggerated thelarche" or "telarche variant" may constitute a diagnostic challenge.
性早熟（乳房过早发育）是青春期前女孩接受内分泌评估的常见原因。它被认为是一种良性病症，但其发病机制仍不清楚。据推测，它可能是由于下丘脑 - 垂体轴的过早部分激活，或者是乳腺组织对正常青春期前雌二醇水平的敏感性增加所致。尽管它很少发展为中枢性性早熟，但鉴别诊断至关重要，因为后一种病症应尽早治疗。所谓的“夸大性乳房过早发育”或“乳房过早发育变异型”可能构成诊断挑战。
