性早熟女童的下丘脑-垂体-促性腺功能
Hypothalamic-pituitary-gonadotropic function in girls with premature thelarche.
作者信息
Pasquino A M, Piccolo F, Scalamandre A, Malvaso M, Ortolani R, Boscherini B
出版信息
Arch Dis Child. 1980 Dec;55(12):941-4. doi: 10.1136/adc.55.12.941.
Abstract
Hypothalamic-pituitary-gonadotropic activity was investigated in 9 girls with premature thelarche, and compared with that in 9 healthy girls and 6 girls with true precocious puberty. The gonadotropin stimulation test with luteinising hormone-releasing hormone was used. Girls with premature thelarche showed luteinising hormone response resembling that of normal girls, and follicle-stimulating hormone (FSH) response quite similar to that of girls with precocious puberty. This suggests that in premature thelarche there is a partial activation of the diencephalic-hypophyseal-gonadal axis, which affects FSH only. Premature thelarche therefore, should be considered as one of the disorders due to altered sensitivity of the hypothalamic receptors which regulate sex maturation.
摘要
对9例乳房过早发育的女孩的下丘脑 - 垂体 - 促性腺激素活性进行了研究，并与9例健康女孩和6例真性性早熟女孩的情况进行了比较。采用促黄体生成素释放激素进行促性腺激素刺激试验。乳房过早发育的女孩的促黄体生成素反应与正常女孩相似，而促卵泡激素（FSH）反应与性早熟女孩非常相似。这表明，在乳房过早发育中，间脑 - 垂体 - 性腺轴存在部分激活，且仅影响FSH。因此，乳房过早发育应被视为由于调节性成熟的下丘脑受体敏感性改变所致的疾病之一。
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