Røodbro P, Christiansen C, Lund M
Acta Neurol Scand. 1975 Aug;52(2):87-93. doi: 10.1111/j.1600-0404.1975.tb05763.x.
The possibility (based on the recognised existence of anticonvulsant osteomalacia), of an osteomalacic origin of a number of subjective symptoms in epileptics (back pain, tiredness, sleepiness, irritability, and giddiness) was tested during a controlled therapeutic trial in 226 outpatients. There was no correlation between subjective symptoms and objective pathological indices of osteomalacia, and group treated with vitamin D (2000 international units daily for 3 months) showed no amelioration of subjective symptoms above that seen in the placebo group. The findings do not support the view that all epileptic patients on anticonvulsant therapy should be treated prophylactically with vitamin D.
在一项针对226名门诊患者的对照治疗试验中，对癫痫患者的一些主观症状（背痛、疲劳、嗜睡、易怒和头晕）是否源于骨软化症（基于已认识到的抗惊厥性骨软化症的存在）进行了测试。主观症状与骨软化症的客观病理指标之间没有相关性，用维生素D治疗的组（每天2000国际单位，持续3个月）与安慰剂组相比，主观症状并未得到改善。这些发现不支持所有接受抗惊厥治疗的癫痫患者都应预防性补充维生素D这一观点。
