Christiansen C, Rodbro P, Nielsen C T
Acta Paediatr Scand. 1975 Mar;64(2):219-24. doi: 10.1111/j.1651-2227.1975.tb03825.x.
Bone mineral content (BMC) ub tge forearms (related to total body calcium) was measured for a controlled therapeutic trial in 25 epileptic children on long-term treatment with phenytoin and in 22 normal children before and during treatment with vitamin D or placebo. In the epileptic children, hypocalcaemia and elevated serum alkaline phosphatase was found in 20% and 16%, respectively. The group of epileptic children treated with vitamin D2 (2000 IU daily) for 3 months showed a significant increase in bone mineral content, 5% on average. The epileptic children treated with placebo showed a significant decrease, 2% on average, while the normal children treated with vitamin D or placebo showed no change in bone mineral content. The results indicate a possible benefit of prophylactic vitamin D treatment in epileptic children.
在一项对照治疗试验中，对25名长期接受苯妥英治疗的癫痫儿童以及22名正常儿童在服用维生素D或安慰剂之前及期间测量了前臂的骨矿物质含量（与全身钙含量相关）。在癫痫儿童中，分别有20%和16%的儿童出现低钙血症和血清碱性磷酸酶升高。接受维生素D2（每日2000国际单位）治疗3个月的癫痫儿童组骨矿物质含量显著增加，平均增加5%。接受安慰剂治疗的癫痫儿童骨矿物质含量显著下降，平均下降2%，而接受维生素D或安慰剂治疗的正常儿童骨矿物质含量没有变化。结果表明预防性维生素D治疗对癫痫儿童可能有益。
