大鼠肝脏线粒体对胆碱的摄取。
The uptake of choline by rat liver mitochondria.
作者信息
de Ridder J J
出版信息
Biochim Biophys Acta. 1976 Nov 9;449(2):236-44. doi: 10.1016/0005-2728(76)90136-5.
PMID:10984
Abstract
- Rat liver mitochondria can accumulate choline against a concentration gradient. Maximally about 30 nmol choline per mg mitochondrial protein are found in the matrix space. 2. The process of choline uptake is biphasic. After a rapid uptake of 1.5-15 nmol per mg protein, a slower uptake occurs if an energy supply is present. In the absence of energy, only the rapid uptake is found. 3. The inhibition of uncoupler-stimulated choline oxidation by cations is the result of an inhibition of choline uptake.
摘要
- 大鼠肝脏线粒体能够逆浓度梯度积累胆碱。在基质空间中，每毫克线粒体蛋白最多可发现约30纳摩尔胆碱。2. 胆碱摄取过程呈双相性。每毫克蛋白快速摄取1.5 - 15纳摩尔胆碱后，如果有能量供应，会出现较慢的摄取过程。在没有能量的情况下，仅发现快速摄取。3. 阳离子对解偶联剂刺激的胆碱氧化的抑制是胆碱摄取受到抑制的结果。
相似文献
1
The uptake of choline by rat liver mitochondria.大鼠肝脏线粒体对胆碱的摄取。
Biochim Biophys Acta. 1976 Nov 9;449(2):236-44. doi: 10.1016/0005-2728(76)90136-5.
2
Loss and maintenance of energy-linked functions in aged mitochondria.衰老线粒体中能量相关功能的丧失与维持
Biochem Biophys Res Commun. 1970 Jun 5;39(5):842-6. doi: 10.1016/0006-291x(70)90399-2.
3
Control of choline oxidation by rat-liver mitochondria.大鼠肝脏线粒体对胆碱氧化的控制
Biochim Biophys Acta. 1975 Nov 11;408(2):112-22. doi: 10.1016/0005-2728(75)90003-1.
4
Dependency of the ATPase and 32 P--ATP exchange reaction of mitochondria on K + and electron transport.线粒体的ATP酶及32P-ATP交换反应对钾离子和电子传递的依赖性。
Arch Biochem Biophys. 1972 Nov;153(1):215-25. doi: 10.1016/0003-9861(72)90439-0.
5
Uncoupler-stimulated oxidation of choline by rat-liver mitochondria.解偶联剂刺激大鼠肝脏线粒体对胆碱的氧化作用。
Biochim Biophys Acta. 1973 Dec 14;325(3):397-405. doi: 10.1016/0005-2728(73)90200-4.
6
The direct in vitro action of gliotoxin on rat liver mitochondria.Gliotoxin对大鼠肝脏线粒体的直接体外作用。
J Antibiot (Tokyo). 1973 Jan;26(1):36-43. doi: 10.7164/antibiotics.26.36.
7
The effect of temperature on mitochondrial membrane-linked reactions.温度对线粒体膜相关反应的影响。
J Biol Chem. 1974 Dec 10;249(23):7541-9.
8
The immediate uptake of potassium ion by mitochondria requiring gramicidin and 2,2-dimethylsuccinic anhydride.需要短杆菌肽和2,2 - 二甲基琥珀酸酐的线粒体对钾离子的快速摄取。
Eur J Biochem. 1976 Oct 1;69(1):315-20. doi: 10.1111/j.1432-1033.1976.tb10888.x.
9
On the mechanism of uncoupler-dependent inhibition of acyl-carnitine oxidation by rat liver mitochondria.大鼠肝脏线粒体中解偶联剂依赖性抑制酰基肉碱氧化的机制
FEBS Lett. 1976 Oct 15;69(1):221-4. doi: 10.1016/0014-5793(76)80691-6.
10
The simultaneous oxidation of substrates by rat liver mitochondria [proceedings].大鼠肝脏线粒体对底物的同时氧化作用[会议论文集]
Biochem Soc Trans. 1978;6(1):161-4. doi: 10.1042/bst0060161.
引用本文的文献
1
F-Choline PET/CT Identifies High-Grade Prostate Cancer Lesions Expressing Bone Biomarkers.F-胆碱正电子发射断层扫描/计算机断层扫描（F-Choline PET/CT）可识别表达骨生物标志物的高级别前列腺癌病灶。
J Clin Med. 2019 Oct 11;8(10):1657. doi: 10.3390/jcm8101657.
2
Transport and metabolism of radiolabeled choline in hepatocellular carcinoma.放射性标记胆碱在肝细胞癌中的转运和代谢。
Mol Pharm. 2010 Dec 6;7(6):2077-92. doi: 10.1021/mp1001922. Epub 2010 Sep 21.
3
Transport and oxidation of choline by liver mitochondria.肝脏线粒体对胆碱的转运与氧化作用。
Biochem J. 1977 Sep 15;166(3):571-81. doi: 10.1042/bj1660571.
Zotero 插件