Lloyd-Still J D, Shwachman H
Am J Dig Dis. 1975 Aug;20(8):708-15. doi: 10.1007/BF01070827.
Culture of the duodenal microflora was performed on 96 infants and children with a variety of gastrointestinal disorders. The resident microflora consists predominantly of oral-type microorganisms such as alpha-Streptococci and Neisseria. A fecal-type microflora was found in all 6 infants with post-surgical diarrhea and temporary monosachcaride intolerance; 4 of 22 patients with protracted diarrhea of infancy, 3 of 22 patients with celiac disease, and none of 32 patients with nonspecific diarrhea or 14 others with miscellaneous disorders. Anaerobic microorganisms were seldom isolated. Only 9% of the duodenal cultures were completely sterile, although a further 17 had a quantitative culture less than 5 times 10(4) microorganisms/ml. Small-bowel contamination with fecal-type microorganisms is associated with stasis and disturbance of the normal peristaltic-clearing mechanism. Duodenal culture is essential in any infant with temporary monosaccharide intolerance. It is occasionally useful in other situations where motility may be disturbed.
对96名患有各种胃肠道疾病的婴幼儿进行了十二指肠微生物群培养。常驻微生物群主要由口腔型微生物组成，如甲型链球菌和奈瑟菌。在所有6名患有术后腹泻和暂时性单糖不耐受的婴儿中发现了粪便型微生物群；在22名婴儿慢性腹泻患者中有4名，在22名乳糜泻患者中有3名，而在32名非特异性腹泻患者或其他14名患有各种疾病的患者中均未发现。厌氧微生物很少分离出来。只有9%的十二指肠培养物完全无菌，尽管另有17份培养物的定量培养结果显示微生物数量低于5×10⁴/ml。小肠被粪便型微生物污染与淤滞和正常蠕动清除机制紊乱有关。十二指肠培养对于任何患有暂时性单糖不耐受的婴儿来说都是必不可少的。在其他可能存在运动功能紊乱的情况下，它偶尔也有用处。
