Taylor B K, Roderick R E, Basbaum A I
Division of Pharmacology, School of Pharmacy, University of Missouri-Kansas City, 2411 Holmes Street, M3-C15, Kansas City, MO 64108, USA.
Neurosci Lett. 2000 Sep 22;291(3):139-42. doi: 10.1016/s0304-3940(00)01389-6.
Nociceptive processing is altered in individuals with inherited hypertension. Because brainstem noradrenergic (NA) neurons have been implicated in both nociceptive transmission and hypertension, we compared behavioral and cardiovascular indices of pain in spontaneously hypertensive rats (SHR) and their normotensive Wistar-Kyoto controls (WKY) after intracerebroventricular administration of an anti-DbetaH-saporin immunotoxin. In WKY rats, NA lesions decreased indices of persistent pain in the formalin test, but did not change nociceptive responses in multiple models of acute pain. In SHR rats, NA lesions did not alter persistent nociception, but decreased thresholds in the hotplate test. We conclude that coeruleospinal inhibitory pathways modulate hypoalgesia but not hyperalgesia in the SHR rat. Brainstem noradrenergic inhibition of acute nociception in the hotplate test is enhanced in the SHR rat, but brainstem noradrenergic contribution to persistent nociceptive processing in the formalin test is reduced in the SHR rat.
遗传性高血压患者的伤害性感受处理会发生改变。由于脑干去甲肾上腺素能（NA）神经元与伤害性感受传递和高血压均有关联，我们在脑室内注射抗多巴胺β羟化酶-皂草素免疫毒素后，比较了自发性高血压大鼠（SHR）及其正常血压的Wistar-Kyoto对照大鼠（WKY）的疼痛行为和心血管指标。在WKY大鼠中，NA损伤降低了福尔马林试验中持续性疼痛的指标，但在多种急性疼痛模型中并未改变伤害性反应。在SHR大鼠中，NA损伤并未改变持续性伤害感受，但降低了热板试验中的阈值。我们得出结论，蓝斑脊髓抑制通路调节SHR大鼠的痛觉减退而非痛觉过敏。在热板试验中，SHR大鼠脑干去甲肾上腺素能对急性伤害感受的抑制作用增强，但在福尔马林试验中，SHR大鼠脑干去甲肾上腺素能对持续性伤害感受处理的贡献降低。
