Dal-Pizzol F, Klamt F, Vianna M M, Schröder N, Quevedo J, Benfato M S, Moreira J C, Walz R
Laboratório de Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, RS, Porto Alegre, Brazil.
Neurosci Lett. 2000 Sep 22;291(3):179-82. doi: 10.1016/s0304-3940(00)01409-9.
Oxidative stress has been implicated in a variety of acute and chronic neurologic conditions, including epilepsy. Both the kainic acid and pilocarpine are useful models of temporal lobe epilepsy in rodents. As an index of lipid peroxidation the level thiobarbituric acid reactive substances (TBARS) was measured after the status epileticus induced by pilocarpine or kainic acid. In hippocampus there was a slight enhancement in the TBARS levels measured 12-14 h after the end of status epileticus induced by pilocarpine and kainic acid. The TBARS levels in pilocarpine treated animals was significantly decreased late after status epileticus and in kainic acid model the TBARS returned to basal levels. These results indicating a putative role of reactive oxygen species in kainic acid and pilocarpine induced epilepsy.
氧化应激与包括癫痫在内的多种急性和慢性神经疾病有关。海藻酸和毛果芸香碱都是啮齿动物颞叶癫痫的有用模型。作为脂质过氧化的指标，在毛果芸香碱或海藻酸诱发癫痫持续状态后测量硫代巴比妥酸反应性物质（TBARS）水平。在由毛果芸香碱和海藻酸诱发癫痫持续状态结束后12 - 14小时测量发现，海马体中的TBARS水平略有升高。在癫痫持续状态后期，毛果芸香碱治疗组动物的TBARS水平显著降低，而在海藻酸模型中，TBARS恢复到基础水平。这些结果表明活性氧在海藻酸和毛果芸香碱诱发的癫痫中可能发挥作用。
