Hanau-Berçot B, Grémy I, Raskine L, Bizet J, Gutierrez M C, Boyer-Mariotte S, Brégeault A, Lagrange P H, Sanson Le Pors M J
Laboratoire de Microbiologie, Centre Hospitalier Universitaire Lariboisière, Paris, France.
Int J Tuberc Lung Dis. 2000 Sep;4(9):853-9.
Ten correctional facilities in Paris, including suburbs.
To prospectively determine the incidence of tuberculosis (TB) in prisons during a one-year period and to trace the transmission of tuberculosis by restriction fragment length polymorphism (RFLP) analysis of Mycobacterium tuberculosis strains from inmates.
Of 93 cases of tuberculosis observed, 50 were culture-confirmed. The incidence of tuberculosis in correctional facilities was 215 cases per 100,000 inmates. A high turnover of inmates was observed. All patients were male, and a quarter had been homeless. Seventy-two per cent were diagnosed with pulmonary tuberculosis. Several severe cases of TB were observed, including three of tuberculous meningitis. No multidrug-resistant strains were noted. RFLP analysis (n = 24) revealed 22 distinct patterns which made up two clusters. Epidemiological investigation did not show direct tuberculosis transmission, which was, however, probable for one cluster.
Independently of incarceration, prison inmates run a higher risk of developing active tuberculosis than the general population, which might be the main reason for the high incidence of tuberculosis observed in prisons. However, some cases of transmission may occur inside prisons.
位于巴黎（包括郊区）的十所惩教机构。
前瞻性地确定监狱中一年内结核病（TB）的发病率，并通过对囚犯结核分枝杆菌菌株进行限制性片段长度多态性（RFLP）分析来追踪结核病的传播情况。
在观察到的93例结核病病例中，50例经培养确诊。惩教机构中结核病的发病率为每10万名囚犯215例。观察到囚犯流动率很高。所有患者均为男性，四分之一曾无家可归。72%被诊断为肺结核。观察到几例严重的结核病病例，包括三例结核性脑膜炎。未发现耐多药菌株。RFLP分析（n = 24）显示出22种不同模式，构成两个簇。流行病学调查未显示结核病的直接传播，但其中一个簇可能存在传播情况。
与监禁无关，监狱囚犯患活动性结核病的风险高于普通人群，这可能是监狱中结核病发病率高的主要原因。然而，监狱内可能会发生一些传播病例。
