局部应用自体血小板裂解液促进静脉性溃疡愈合的随机双盲安慰剂对照试验
Randomised double-blind placebo controlled trial of topical autologous platelet lysate in venous ulcer healing.
作者信息
Stacey M C, Mata S D, Trengove N J, Mather C A
机构信息
University Department of Surgery, Fremantle Hospital, Fremantle, WA 6160, Australia.
出版信息
Eur J Vasc Endovasc Surg. 2000 Sep;20(3):296-301. doi: 10.1053/ejvs.2000.1134.
OBJECTIVES
to assess the effect of topical autologous platelet lysate on the healing of chronic venous ulcers.
DESIGN
a randomised placebo controlled double-blind trial.
MATERIALS
all patients had blood taken for preparation of autologous platelet lysate.
METHODS
patients with proven chronic venous ulceration were randomised to the trial. Autologous platelet lysate or placebo buffer solution were applied twice per week for up to 9 months in combination with standardised compression bandaging.
RESULTS
a total of 86 patients (36 males and 50 females, median age 70 years) were entered into the study. The patient and treatment groups were equivalent for ulcer size, ulcer duration and other characteristics. Cox regression analysis of the time to ulcer healing did not show any difference in healing between platelet lysate and placebo application.
CONCLUSIONS
platelet lysate prepared and delivered by the method used in this study had no influence on the healing of chronic venous ulceration.
目的
评估局部应用自体血小板裂解液对慢性静脉溃疡愈合的影响。
设计
一项随机、安慰剂对照、双盲试验。
材料
所有患者均采血以制备自体血小板裂解液。
方法
确诊为慢性静脉溃疡的患者被随机纳入试验。自体血小板裂解液或安慰剂缓冲溶液每周应用两次，持续长达9个月，并结合标准化的加压包扎。
结果
共有86例患者（36例男性和50例女性，中位年龄70岁）纳入研究。患者组和治疗组在溃疡大小、溃疡持续时间及其他特征方面相当。对溃疡愈合时间的Cox回归分析显示，应用血小板裂解液和安慰剂之间在愈合方面无差异。
结论
本研究采用的方法制备和递送的血小板裂解液对慢性静脉溃疡的愈合没有影响。
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