Pyle R B, Helton W C, Johnson F W, Hornung J R, Hunt C E, Trumball H R, Lindsay W G, Nicoloff D M
Arch Surg. 1975 Aug;110(8):966-70. doi: 10.1001/archsurg.1975.01360140110022.
Since April 1973 we have treated nine patients with extracorporeal membrane oxygenation (ECMO), utilizing the spiral coil membrane lung. One patient is a long-term survivor. All patients except one showed substantial improvement in peripheral arterial oxygen tension. Four adults and two neonates were treated for critical hypoxia. Two patients were treated for cardiac failure but failed to show improved myocardial function. Complications involving perfusion circuitry, cannulation, chronic systemic heparinization, thrombocytopenia, and renal failure have been managed with minimal difficulty. However, irreversible pulmonary, neurologic, hepatic, or gastrointestinal damage due to hypoxia present before the institution of ECMO was associated with lethal complications. The ECMO has supplied adequate oxygenation to this group of nine critically hypoxic patients. Institution of ECMO at an earlier date in patients with critical hypoxia would provide a higher likelihood of survival.
自1973年4月以来，我们使用螺旋线圈膜肺对9例患者进行了体外膜肺氧合（ECMO）治疗。1例患者长期存活。除1例患者外，所有患者的外周动脉血氧张力均有显著改善。4名成年人和2名新生儿因严重缺氧接受治疗。2名患者因心力衰竭接受治疗，但心肌功能未改善。涉及灌注回路、插管、慢性全身肝素化、血小板减少症和肾衰竭的并发症处理起来难度最小。然而，在开始ECMO治疗前就已存在的缺氧导致的不可逆肺、神经、肝或胃肠道损伤与致命并发症相关。ECMO已为这9例严重缺氧患者提供了充足的氧合。对于严重缺氧患者，更早开始ECMO治疗将提供更高的存活可能性。
