与胆碱酯酶结构相关的季铵盐8-羟基喹啉和8-羟基喹哪啶-氨基甲酸酯的合成。
Synthesis of quaternary 8-hydroxyquinoline and 8-hydroxyquinaldine-carbamates structurally related to cholinesterase.
作者信息
Badawi A M, Hassan A B
出版信息
Pharmazie. 1979;34(3):142-4. doi: 10.1002/chin.197928258.
PMID:109867
Abstract
The quaternary carbamates were synthesized by reaction of 8-hydroxyquinoline and 8-hydroxyquinaldine with alkylisocyanates, then quaternizing the carbamates produced with alkylhalides, aralkylhalides or sulphate. The UV spectra of the compounds obtained showed lambdamax at 285 nm. The new quaternary carbamates were found to be of high toxicity and parasymapathomimetic activity in white mice.
摘要
通过8-羟基喹啉和8-羟基喹哪啶与烷基异氰酸酯反应合成季铵基氨基甲酸盐，然后用烷基卤化物、芳烷基卤化物或硫酸盐将生成的氨基甲酸盐季铵化。所得化合物的紫外光谱显示最大吸收波长在285nm。发现新的季铵基氨基甲酸盐对白鼠具有高毒性和拟副交感神经活性。
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