Al-Qarawi A A, Ali B H, Abdel-Gayoum A G
Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine King Saud University, Buraydah, Saudi Arabia.
Exp Toxicol Pathol. 2000 Aug;52(4):364-6. doi: 10.1016/S0940-2993(00)80064-0.
Rats were treated orally with furazolidone (FZ) at doses of 50, 100, and 200 mg/kg body weight for three consecutive days. The parameters determined in plasma included: total cholesterol, high density (HDL) cholesterol, low-density (VLDL+LDL) cholesterol, triglycerol (TAG), phospholipids (PL), and lipoprotein lipase. In the liver, cholesterol, TAG and phospholipid concentrations were measured. At the lowest dose used, no statistically significant effect on any of these parameters in plasma or liver was observed. The drug, dose-dependently, increased the concentrations of total cholesterol, VLDL cholesterol, TAG and PL in plasma. The activity of lipoprotein lipase was significantly decreased by FZ by about 45%. The hepatic cholesterol concentration was not significantly affected by any of the doses used. However, doses of 100 and 200 mg/kg produced fatty infiltration in the liver and significantly increased TAG level. The highest dose also decreased PL concentration.
大鼠连续三天口服剂量为50、100和200毫克/千克体重的呋喃唑酮（FZ）。血浆中测定的参数包括：总胆固醇、高密度（HDL）胆固醇、低密度（VLDL+LDL）胆固醇、甘油三酯（TAG）、磷脂（PL）和脂蛋白脂肪酶。在肝脏中，测量胆固醇、TAG和磷脂浓度。在所使用的最低剂量下，未观察到对血浆或肝脏中的任何这些参数有统计学上的显著影响。该药物剂量依赖性地增加了血浆中总胆固醇、VLDL胆固醇、TAG和PL的浓度。FZ使脂蛋白脂肪酶的活性显著降低约45%。所使用的任何剂量均未对肝脏胆固醇浓度产生显著影响。然而，100和200毫克/千克的剂量导致肝脏脂肪浸润并显著提高TAG水平。最高剂量还降低了PL浓度。
