Valeriote F, van Putten L
Cancer Res. 1975 Oct;35(10):2619-30.
One of the factors of importance in determining the killing of mammalian cells following exposure to a variety of anticancer agents is the proliferative state of the cell population. Generally, proliferating cells are much more sensitive to anticancer agents than are nonproliferating cells. In this review, the cellular aspects of this differential sensitivity are discussed with the hemopoietic stem cell population and tissue culture cells as the focus for the analysis. This phenomenon is not only of concern to the cell biologist but also has implications with regard to scheduling of anticancer agents against human tumors.
在确定哺乳动物细胞暴露于各种抗癌剂后被杀伤的重要因素之一是细胞群体的增殖状态。一般来说，增殖细胞比非增殖细胞对抗癌剂敏感得多。在这篇综述中，以造血干细胞群体和组织培养细胞为分析重点，讨论了这种差异敏感性的细胞方面。这种现象不仅是细胞生物学家所关注的，而且对抗癌剂治疗人类肿瘤的用药安排也有影响。
