Yamada K, Furukawa T
Psychopharmacology (Berl). 1979 Mar 28;61(3):255-60. doi: 10.1007/BF00432268.
We examined the relationship between lithium-induced head twitches and serotonergic neurons. Head twitches were elicited by combined treatment with lithium chloride (2 or 5 mEq/kg x 5, s.c. administered hourly) and rauwolfia alkaloids, i.e., reserpine (5 mg/kg, s.c.), tetrabenazine (20 mg/kg, s.c.), and syrosingopine (10 mg/kg, s.c.). Neither lithium nor the alkaloid alone induced the twitches; nor did combined administration of lithium with methamphetamine or p-chloroamphetamine. The head twitches induced by lithium in combination with reserpine were strongly inhibited by antiserotonin drugs, methysergide and cyproheptadine, and also by a serotonin synthesis inhibitor, p-chlorophenylalanine (PCPA), when administered between lithium and reserpine. When PCPA was administered before lithium for 3 days, the head twitches were potentiated. In addition, the head twitches were potentiated by a serotonin receptor stimulant, 5-methoxy-N,N-dimethyltryptamine. The results imply that lithium can induce head twitches in the presence of rauwolfia alkaloids and may exert its effect in part by acting on the serotonergic neuron system.
我们研究了锂诱导的头部抽搐与血清素能神经元之间的关系。头部抽搐是通过联合使用氯化锂（2或5 mEq/kg×5，每小时皮下注射）和萝芙木生物碱引发的，即利血平（5 mg/kg，皮下注射）、丁苯那嗪（20 mg/kg，皮下注射）和辛可卡因（10 mg/kg，皮下注射）。单独使用锂或生物碱均不会诱发抽搐；锂与甲基苯丙胺或对氯苯丙胺联合给药也不会诱发抽搐。锂与利血平联合诱导的头部抽搐，在锂和利血平之间给药时，会被抗血清素药物麦角新碱和赛庚啶以及血清素合成抑制剂对氯苯丙氨酸（PCPA）强烈抑制。当在锂给药前3天给予PCPA时，头部抽搐会增强。此外，血清素受体兴奋剂5-甲氧基-N,N-二甲基色胺会增强头部抽搐。结果表明，锂在存在萝芙木生物碱的情况下可诱导头部抽搐，并且可能部分通过作用于血清素能神经元系统发挥其作用。
