[Helicobacter pylori and non-steroidal anti-inflammatory agents].

Observations on the interactions between the two main causes of gastroduodenal lesions--treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori(H.p.)-infection--remain controversial. However, H.p.-infection does not need to be harmful additively or synergistically, but could also be protective against the toxic effects of NSAIDs on the mucosa. Therefore, specific therapeutic strategies are needed for different clinical situations.