在使用促性腺激素释放激素（LHRH）进行长期治疗期间出现的继发性药物失效：抗体的出现。
Secondary drug failure occurring during chronic treatment with LHRH: appearance of an antibody.
作者信息
Van Loon G R, Brown G M
出版信息
J Clin Endocrinol Metab. 1975 Sep;41(3):640-3. doi: 10.1210/jcem-41-3-640.
PMID:1099116
Abstract
Secondary drug failure with regard to subjective and hormonal responses occurred in a patient treated chronically with LHRH. This failure of response to hormone therapy was correlated with increased binding of 125I-LHRH by the patient's sera. Also, competitive displacement of 125I-LHRH by unlabelled LHRH was demonstrated. Affinity constants and titers of order appropriate for antibody were obtained. These data support strongly a report of antibody formation to exogenous LHRH in man.
摘要
一名长期接受促性腺激素释放激素（LHRH）治疗的患者出现了关于主观和激素反应的继发性药物失效。这种对激素治疗的反应失效与患者血清中125I-LHRH结合增加相关。此外，还证实了未标记的LHRH对125I-LHRH的竞争性置换。获得了适合抗体的亲和力常数和效价。这些数据有力地支持了关于人类对外源性LHRH形成抗体的报道。
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