粪肠球菌中高水平氨基糖苷类耐药基因aph(2")-Ib的检测
Detection of the high-level aminoglycoside resistance gene aph(2")-Ib in Enterococcus faecium.
作者信息
Kao S J, You I, Clewell D B, Donabedian S M, Zervos M J, Petrin J, Shaw K J, Chow J W
机构信息
Research and Medical Service, John D. Dingell VA Medical Center, and Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
出版信息
Antimicrob Agents Chemother. 2000 Oct;44(10):2876-9. doi: 10.1128/AAC.44.10.2876-2879.2000.
Abstract
A new high-level gentamicin resistance gene, designated aph(2")-Ib, was cloned from Enterococcus faecium SF11770. The deduced amino acid sequence of the 897-bp open reading frame of aph(2")-Ib shares homology with the aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(2")-Ic, and APH(2")-Id. The observed phosphotransferase activity is designated APH(2")-Ib.
摘要
从屎肠球菌SF11770中克隆出一个新的高水平庆大霉素抗性基因，命名为aph(2")-Ib。aph(2")-Ib的897个碱基对开放阅读框推导的氨基酸序列与氨基糖苷修饰酶AAC(6')-APH(2")、APH(2")-Ic和APH(2")-Id具有同源性。所观察到的磷酸转移酶活性被命名为APH(2")-Ib。
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