铜绿假单胞菌中一个新的染色体氨基糖苷磷酸转移酶基因aph(3')-IIb的序列及特性分析
Sequence and characterization of a novel chromosomal aminoglycoside phosphotransferase gene, aph (3')-IIb, in Pseudomonas aeruginosa.
作者信息
Hächler H, Santanam P, Kayser F H
机构信息
Institute of Medical Microbiology, University of Zürich, Switzerland.
出版信息
Antimicrob Agents Chemother. 1996 May;40(5):1254-6. doi: 10.1128/AAC.40.5.1254.
Abstract
A novel, probably chromosomally encoded, aminoglycoside phosphotransferase gene was cloned on a 2,996-bp PstI fragment from Pseudomonas aeruginosa and designated aph (3')-IIb. It coded for a protein of 268 amino acids that showed 51.7% amino acid identity with APH (3')-II [APH(3') is aminoglycoside-3' phosphotransferase] from Tn5. Two other open reading frames on the cloned fragment showed homology to a signal-transducing system in P. aeruginosa.
摘要
从铜绿假单胞菌中克隆出一个新的、可能由染色体编码的氨基糖苷磷酸转移酶基因，该基因位于一个2996 bp的PstI片段上，命名为aph(3')-IIb。它编码一种由268个氨基酸组成的蛋白质，与来自Tn5的APH(3')-II[APH(3')是氨基糖苷-3'磷酸转移酶]的氨基酸同一性为51.7%。克隆片段上的另外两个开放阅读框与铜绿假单胞菌中的一个信号转导系统具有同源性。
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