Uemura T, Liu Y K, Kuboki Y
National Institute for Advanced Interdisciplinary Research, Tsukuba Research Center, Ibaraki, Japan.
Biosci Biotechnol Biochem. 2000 Aug;64(8):1771-3. doi: 10.1271/bbb.64.1771.
We demonstrated that the transcriptional expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts were regulated by different matrix proteins that bind to integrin on osteoclast, such as collagen type I (CoI), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory. Results suggested that the OPN-integrin alphavbeta3 binding plays a more important role than CoI-alpha2beta1 binding in the regulation of osteoclast activity.
我们证明，在高度富集的破骨细胞中，MT1-MMP、MMP-9、组织蛋白酶K和抗酒石酸酸性磷酸酶的转录表达受不同基质蛋白的调节，这些基质蛋白与破骨细胞上的整合素结合，如I型胶原（CoI）、纤连蛋白（FN）、玻连蛋白（VN）、骨桥蛋白（OPN）和象牙。结果表明，在破骨细胞活性调节中，OPN-整合素αvβ3结合比CoI-α2β1结合发挥更重要的作用。
