初步交流。MT1-MMP、MMP-9、组织蛋白酶K和抗酒石酸酸性磷酸酶在几种基质蛋白和象牙表面培养的高度富集破骨细胞中的mRNA表达。
Preliminary communication. MRNA expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts cultured on several matrix proteins and ivory surfaces.
作者信息
Uemura T, Liu Y K, Kuboki Y
机构信息
National Institute for Advanced Interdisciplinary Research, Tsukuba Research Center, Ibaraki, Japan.
出版信息
Biosci Biotechnol Biochem. 2000 Aug;64(8):1771-3. doi: 10.1271/bbb.64.1771.
We demonstrated that the transcriptional expression of MT1-MMP, MMP-9, cathepsin K, and TRAP in highly enriched osteoclasts were regulated by different matrix proteins that bind to integrin on osteoclast, such as collagen type I (CoI), fibronectin (FN), vitronectin (VN), osteopontin (OPN), and ivory. Results suggested that the OPN-integrin alphavbeta3 binding plays a more important role than CoI-alpha2beta1 binding in the regulation of osteoclast activity.
我们证明，在高度富集的破骨细胞中，MT1-MMP、MMP-9、组织蛋白酶K和抗酒石酸酸性磷酸酶的转录表达受不同基质蛋白的调节，这些基质蛋白与破骨细胞上的整合素结合，如I型胶原（CoI）、纤连蛋白（FN）、玻连蛋白（VN）、骨桥蛋白（OPN）和象牙。结果表明，在破骨细胞活性调节中，OPN-整合素αvβ3结合比CoI-α2β1结合发挥更重要的作用。
Zotero 插件