Matsumura Y, Kita S, Ohgushi R, Okui T
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Biol Pharm Bull. 2000 Sep;23(9):1041-5. doi: 10.1248/bpb.23.1041.
The effect of sesamin, a lignan from sesame oil, on altered vasodilator and vasoconstrictor responses in aortic rings from deoxycorticosterone acetate (DOCA)-salt-induced hypertensive rats, were examined. The systolic blood pressure after 5-weeks DOCA-salt treatment was 195.0+/-2.8 mmHg, which was much higher than that of sham-operated control animals (131.2+/-2.4 mmHg). Sesamin feeding significantly suppressed the development of this hypertension (167.1+/-8.6 mmHg). Acetylcholine (ACh)-induced endothelium-dependent relaxation of aortic rings was markedly decreased in the DOCA-salt hypertensive animals, compared with cases of the control (pD2, 7.0+/-0.1; maximal response, 64.8+/-3.4% versus pD2, 7.7+/-0.2; maximal response, 93.3+/-2.7%). These changes were partially but significantly improved by the sesamin feeding. This improvement seems to be related to a nitric oxide (NO)-dependent component of ACh-induced action, because sesamin feeding did not affect the responses to ACh in the presence of NO synthase inhibitor. A spontaneous NO releaser (+/-)-(E)-4-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (NOR 3) which exerts endothelium-independent vasodilatation, produced the same patterns of responses as those observed with ACh in cases of DOCA-salt treatment and sesamin feeding. Phenylephrine-induced vasoconstriction was enhanced by the DOCA-salt treatment, both in preparations with and without endothelium, but these enhancements were almost completely normalized by sesamin feeding. Thus, dietary sesamin could efficiently improve the abnormal vasodilator and vasoconstrictor responses in DOCA-salt hypertensive animals. These effects may contribute to the antihypertensive activity of sesamin.
研究了芝麻油中的木脂素芝麻素对醋酸脱氧皮质酮（DOCA）-盐诱导的高血压大鼠主动脉环中血管舒张和血管收缩反应改变的影响。DOCA-盐处理5周后的收缩压为195.0±2.8 mmHg，远高于假手术对照动物（131.2±2.4 mmHg）。喂食芝麻素可显著抑制这种高血压的发展（167.1±8.6 mmHg）。与对照组相比，DOCA-盐高血压动物中乙酰胆碱（ACh）诱导的主动脉环内皮依赖性舒张明显降低（pD2，7.0±0.1；最大反应，64.8±3.4% 对比 pD2，7.7±0.2；最大反应，93.3±2.7%）。喂食芝麻素可部分但显著改善这些变化。这种改善似乎与ACh诱导作用中依赖一氧化氮（NO）的成分有关，因为在存在一氧化氮合酶抑制剂的情况下，喂食芝麻素并不影响对ACh的反应。一种自发释放NO的物质（±）-（E）-4-乙基-2-[(E)-羟基亚氨基]-5-硝基-3-己烯酰胺（NOR 3），其产生不依赖内皮的血管舒张作用，在DOCA-盐处理和喂食芝麻素的情况下产生与ACh相同的反应模式。去氧肾上腺素诱导的血管收缩在DOCA-盐处理下无论是有内皮还是无内皮的制剂中均增强，但这些增强在喂食芝麻素后几乎完全恢复正常。因此，饮食中的芝麻素可有效改善DOCA-盐高血压动物异常的血管舒张和血管收缩反应。这些作用可能有助于芝麻素的降压活性。
