Matsumura Y, Kita S, Tanida Y, Taguchi Y, Morimoto S, Akimoto K, Tanaka T
Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan.
Biol Pharm Bull. 1998 May;21(5):469-73. doi: 10.1248/bpb.21.469.
The antihypertensive effect of sesamin, a lignan from sesame oil, was examined using salt-loaded and unloaded stroke-prone spontaneously hypertensive rats (SHRSP). The animals at 6 weeks of age were separated into a salt-loaded group and an unloaded group. Salt-loaded animals were maintained on 1% NaCl drinking water. Each group was further divided into two groups: normal-diet group and sesamin-diet group. Systolic blood pressure of all animals was monitored once weekly. At the end of the feeding periods, cardiovascular hypertrophy and renal damage were evaluated. In the salt-loaded group, sesamin feeding significantly suppressed the development of hypertension, and efficient suppression was maintained from 9 to 26 weeks (e.g., 215+/-4 vs. 180+/-4 mmHg, at 17 weeks old). The left ventricle plus septum weight-to-body weight ratio was slightly but significantly lowered by sesamin feeding. When the degree of vascular hypertrophy of the aorta and superior mesenteric artery was histochemically evaluated, wall thickness and wall area of these vessels were significantly decreased by the sesamin feeding. Histological renal damage such as thickening of the tunica intima and fibrinoid degeneration of the arterial wall were often observed in the normal-diet group, but this damage was efficiently reduced in the sesamin-fed animals. On the other hand, in the salt-unloaded group, only a slight and nonsignificant suppressive effect of sesamin on the development of hypertension was observed. Although the wall area of the aorta was significantly decreased by the sesamin feeding, other vascular parameters were not ameliorated. The incidence of histological renal damage tended to decrease in sesamin-fed animals, but these alterations were not statistically significant. Thus, sesamin feeding was much more effective as an antihypertensive regimen in salt-loaded SHRSP than in unloaded SHRSP, thereby suggesting that sesamin is more useful as a prophylactic treatment in the malignant status of hypertension and/or hypertension followed by water and salt retention.
利用盐负荷和非盐负荷的易发性中风自发性高血压大鼠（SHRSP），研究了芝麻油中的木脂素芝麻素的降压作用。将6周龄的动物分为盐负荷组和非盐负荷组。盐负荷动物饮用含1%氯化钠的水。每组再分为两组：正常饮食组和芝麻素饮食组。每周监测所有动物的收缩压。在喂养期结束时，评估心血管肥大和肾损伤情况。在盐负荷组中，芝麻素喂养显著抑制了高血压的发展，并且从9周到26周都保持了有效的抑制作用（例如，17周龄时，收缩压为215±4 mmHg对180±4 mmHg）。芝麻素喂养使左心室加室间隔重量与体重之比略有但显著降低。当通过组织化学方法评估主动脉和肠系膜上动脉的血管肥大程度时，芝麻素喂养使这些血管的壁厚度和壁面积显著减小。在正常饮食组中经常观察到组织学上的肾损伤，如内膜增厚和动脉壁的纤维蛋白样变性，但在喂食芝麻素的动物中，这种损伤得到了有效减轻。另一方面，在非盐负荷组中，仅观察到芝麻素对高血压发展有轻微且不显著的抑制作用。尽管芝麻素喂养使主动脉的壁面积显著减小，但其他血管参数并未得到改善。在喂食芝麻素的动物中，组织学肾损伤的发生率有降低趋势，但这些改变无统计学意义。因此，在盐负荷的SHRSP中，芝麻素喂养作为一种降压方案比在非盐负荷的SHRSP中更有效，这表明芝麻素在高血压的恶性状态和/或伴有水盐潴留的高血压的预防性治疗中更有用。
