Wada A, Nomoto Y, Tano K, Yamashita E, Ito M
Kobe Pharmaceutical University, Higashinada, Japan.
Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1391-4. doi: 10.1248/cpb.48.1391.
Palladium catalyzed cross coupling reactions of a vinyl triflate intermediate and various alkenyl stannanes afforded trisubstituted Z-olefins stereoselectively in high yields. These olefins were then converted to the corresponding 9Z-retinoic acids via Horner-Emmons reaction and subsequent basic hydrolysis in excellent yields.
钯催化乙烯基三氟甲磺酸酯中间体与各种烯基锡烷的交叉偶联反应，以高产率立体选择性地得到三取代的Z-烯烃。然后通过霍纳尔-埃蒙斯反应以及随后的碱性水解，将这些烯烃以优异的产率转化为相应的9Z-视黄酸。
