Máximo V, Sobrinho-Simões M
Institute of Molecular Pathology and Immunology of the University of Porto, Portugal.
Virchows Arch. 2000 Aug;437(2):107-15. doi: 10.1007/s004280000219.
The molecular and enzymatic abnormalities of mitochondria in oxyphilic / oncocytic / Hürthle cells and their respective tumours are reviewed in a series of sections: "Mitochondria, ageing, neurodegenerative diseases and cancer", "Mitochondrial abnormalities in Hürthle cells and Hürthle cells tumours", "Mitochondrion-related alterations in tumours with and without Hürthle cell/oncocytic features", "True and secondary oxyphilia", and "Bcl-2 expression, apoptosis and necrosis in Hürthle cell tumours and tumour-like lesions". The clinicopathological and pathogenetic meaning of the data on record on these topics are discussed, with an emphasis on thyroid pathology.
在一系列章节中综述了嗜酸性/嗜酸性粒细胞/许特莱细胞及其各自肿瘤中线粒体的分子和酶异常情况：“线粒体、衰老、神经退行性疾病和癌症”、“许特莱细胞和许特莱细胞瘤中的线粒体异常”、“具有和不具有许特莱细胞/嗜酸性粒细胞特征的肿瘤中线粒体相关改变”、“真性和继发性嗜酸性变”以及“许特莱细胞瘤和肿瘤样病变中的Bcl-2表达、凋亡和坏死”。讨论了这些主题相关记录数据的临床病理和发病机制意义，重点是甲状腺病理学。
