Dich J, Grunnet N, Lammert O, Faber P, Bjørnsbo K S, Larsen L O, Neese R A, Hellerstein M C, Quistorff B
Københavns Universitet, Det Sundhedsvidenskabelige Fakultet, Panum Instituttet, Institut for Medicinsk Biokemi og Genetik.
Ugeskr Laeger. 2000 Sep 4;162(36):4794-9.
Ten pairs of normal young men were overfed by 5 MJ per day for 21 days with either a carbohydrate-rich or a fat-rich diet (C- and F-group). The two subjects of a pair were requested to follow each other throughout the day to ensure similar physical activity. The increase in body weight and fat mass were not significantly different between the C- and the F-group. Heat production during sleep did not change during overfeeding. The accumulated faecal loss of energy, dry matter, carbohydrate and protein was significantly higher in the C- than in the F-group. Hepatic de novo lipogenesis was 212 g per 21 days in the C-group and was too low to be determined in the F-group. Whole body de novo lipogenesis was positive in six of the ten subjects in the C-group (mean: 332 g per 21 days). It is concluded that the increase in body weight and fat mass during overfeeding of isocaloric amounts of diets rich in carbohydrate or in fat was not significantly different, and that surplus of carbohydrate seemed to be converted to fat both by hepatic and extrahepatic de novo lipogenesis.
十对正常青年男性，分别给予富含碳水化合物或富含脂肪的饮食（碳水化合物组和脂肪组），每天额外多摄入5兆焦耳热量，持续21天。要求每对中的两名受试者全天相互跟随，以确保身体活动相似。碳水化合物组和脂肪组之间体重和脂肪量的增加没有显著差异。过度喂养期间睡眠时的产热没有变化。碳水化合物组粪便中能量、干物质、碳水化合物和蛋白质的累积损失显著高于脂肪组。碳水化合物组肝脏从头脂肪生成量为每21天212克，脂肪组过低无法测定。碳水化合物组十名受试者中有六名全身从头脂肪生成呈阳性（平均：每21天332克）。结论是，等热量的富含碳水化合物或脂肪的饮食过度喂养期间，体重和脂肪量的增加没有显著差异，碳水化合物过剩似乎通过肝脏和肝脏外从头脂肪生成转化为脂肪。
