Crotty K A
Department of Anatomical Pathology, Royal Prince Alfred Hospital.
Australas J Dermatol. 1997 Jun;38 Suppl 1:S49-53. doi: 10.1111/j.1440-0960.1997.tb01010.x.
Spitz naevus is a benign lesion that can be confused histologically with malignant melanoma. Some malignant melanomas also have an appearance similar to a Spitz naevus. Spitz naevus commonly occurs in children but also occurs in adults. The typical Spitz naevus has a classical histological appearance. This paper reviews several studies which have attempted to develop criteria to separate malignant melanoma and Spitz naevi. Histological features that suggest a diagnosis of malignant melanoma rather than atypical Spitz naevus include deep and marginal mitoses, atypical mitoses, asymmetry, pleomorphism and prominent epidermal involvement.
斯皮茨痣是一种良性病变，在组织学上可能与恶性黑色素瘤混淆。一些恶性黑色素瘤的外观也与斯皮茨痣相似。斯皮茨痣常见于儿童，但也见于成人。典型的斯皮茨痣具有经典的组织学表现。本文综述了几项试图制定区分恶性黑色素瘤和斯皮茨痣标准的研究。提示诊断为恶性黑色素瘤而非非典型斯皮茨痣的组织学特征包括深部和边缘有丝分裂、非典型有丝分裂、不对称、多形性和显著的表皮累及。
