Okun M R
Dermatopathology Foundation, Canton, Massachusetts 02021, USA.
Histopathology. 1998 Aug;33(2):158-62. doi: 10.1046/j.1365-2559.1998.00443.x.
The objective of this study was to determine the validity of sharpness of lateral margins (an important component of the pattern analysis method) as a criterion for the histological distinction of naevi from malignant melanoma.
The sharpness of lateral borders in a series of histologically unequivocal malignant melanomas, Spitz naevi and compound naevi, chosen at random from dermatopathology slide archives, was determined. The incidence of poor demarcation of lateral borders in malignant melanomas was about equal to that of Spitz naevi and was significantly less than in compound naevi. The sharpness of lateral borders frequently varies with level of sectioning.
The proposal that malignant melanomas have a significantly greater incidence of poor demarcation of lateral borders than benign melanocytic neoplasms (Spitz naevi and compound naevi) was shown to be without validity on cited empirical grounds as well as theoretical grounds (the lack of constancy of pattern from a 3-dimensional standpoint).
本研究的目的是确定外侧边缘清晰度（模式分析方法的一个重要组成部分）作为区分痣与恶性黑色素瘤组织学标准的有效性。
从皮肤病理学玻片档案中随机选取一系列组织学明确的恶性黑色素瘤、Spitz痣和复合痣，确定其外侧边界的清晰度。恶性黑色素瘤外侧边界分界不清的发生率与Spitz痣大致相同，且显著低于复合痣。外侧边界的清晰度常因切片水平而异。
基于引用的实证依据以及理论依据（从三维角度看模式缺乏稳定性），恶性黑色素瘤外侧边界分界不清的发生率显著高于良性黑素细胞肿瘤（Spitz痣和复合痣）这一观点被证明是无效的。
