Bouldin M B, Clowers-Webb H E, Davis J L, McEvoy M T, Davis M D
Department of Dermatology, Mayo Clinic, Rochester, Minn 55905, USA.
Mayo Clin Proc. 2000 Sep;75(9):967-70. doi: 10.4065/75.9.967.
Linear IgA bullous dermatosis (LABD) is an acquired autoimmune subepidermal blistering disorder in which linear deposits of IgA are found along the basement membrane. Idiopathic, systemic disorder-related, and drug-induced forms of LABD have been described. Drug-induced LABD occurs in association with drug administration and resolves when the offending agent is discontinued. Other forms of LABD assume a more chronic course. The nonsteroidal anti-inflammatory drugs piroxicam and diclofenac have been previously reported to induce LABD. To our knowledge, this article describes the first documented case of LABD associated with naproxen administration, which resolved after discontinuation of the drug.
线状IgA大疱性皮肤病（LABD）是一种获得性自身免疫性表皮下大疱性疾病，其特征是在基底膜处发现IgA的线状沉积。LABD有特发性、与全身性疾病相关以及药物诱导等多种类型。药物诱导的LABD与药物使用相关，停用致病药物后可缓解。其他类型的LABD病程则更为慢性。非甾体类抗炎药吡罗昔康和双氯芬酸此前已有诱发LABD的报道。据我们所知，本文描述了首例有记录的与萘普生使用相关的LABD病例，该病例在停药后病情缓解。
