Cummings Julie E, Snyder Renee R, Kelly Erica B, Raimer Sharon S
University of Texas Medical Branch, Galveston TX 77550, USA.
Cutis. 2007 Mar;79(3):203-7.
Linear immunoglobulin A (IgA) bullous dermatosis (LABD) is a rare autoimmune disorder characterized by vesiculobullous mucocutaneous eruptions. LABD also has been reported as a drug-induced reaction. Idiopathic LABD and drug-induced LABD are clinically indistinguishable and can resemble bullous pemphigoid, dermatitis herpetiformis, or bullous erythema multiforme. LABD is diagnosed with direct immunofluorescence (DIF), and idiopathic LABD can be distinguished from drug-induced LABD with a careful medication history. We present the case of a 54-year-old man with drug-induced LABD after ingestion of rimantadine, zanamivir, and azithromycin for presumed influenza. The patient's bullous eruption resolved with discontinuation of the offending medications and treatment with prednisone and pentoxifylline.
线状免疫球蛋白A（IgA）大疱性皮肤病（LABD）是一种罕见的自身免疫性疾病，其特征为水疱大疱性黏膜皮肤疹。LABD也被报道为药物诱导反应。特发性LABD和药物诱导的LABD在临床上难以区分，且可能类似于大疱性类天疱疮、疱疹样皮炎或大疱性多形红斑。LABD通过直接免疫荧光（DIF）进行诊断，通过仔细询问用药史可将特发性LABD与药物诱导的LABD区分开来。我们报告了一例54岁男性在服用金刚烷胺、扎那米韦和阿奇霉素治疗疑似流感后发生药物诱导的LABD的病例。停用致病药物并使用泼尼松和己酮可可碱治疗后，患者的水疱疹消退。
