Dubový P
Department of Anatomy, School of Medicine, Masaryk University Brno, Czech Republic.
Anat Embryol (Berl). 2000 Sep;202(3):235-45. doi: 10.1007/s004290000105.
The capsule and inner core are multilamellar auxiliary structures enveloping the axon terminal of the Pacinian corpuscle. The freezing injury of the rat interosseal Pacinian corpuscles induced the destruction of all cellular components while the extracellular matrix including the basal laminae survive the treatment. Simultaneous denervation and the freezing treatment of the Pacinian corpuscles discovered an ability of the basal lamina and other components of the extracellular matrix to stimulate a differentiation of migrated Schwann cells and fibroblasts into multilamellar auxiliary structures. The restoration of inner core and capsule in the Pacinian corpuscles was independent of the presence of sensory axon terminals. The restored lamellar structures of Pacinian corpuscles in long-term surviving rat (4 to 8 months) displayed atrophic changes. The results suggest that the extracellular matrix of rat Pacinian corpuscles may contain molecules that are produced by Schwann cells and fibroblasts during maturation of the multilamellar auxiliary structures. The molecules deposited into the extracellular matrix are able to influence the redifferentiation of multilamellar auxiliary structures from immature cells.
被膜和内核是包裹环层小体轴突终末的多层辅助结构。大鼠骨间环层小体的冷冻损伤导致所有细胞成分遭到破坏，而包括基膜在内的细胞外基质在该处理中存活下来。对环层小体进行同时去神经支配和冷冻处理发现，基膜和细胞外基质的其他成分具有刺激迁移的雪旺细胞和成纤维细胞分化为多层辅助结构的能力。环层小体内核和被膜的恢复与感觉轴突终末的存在无关。长期存活大鼠（4至8个月）中环层小体恢复的板层结构显示出萎缩性变化。结果表明，大鼠环层小体的细胞外基质可能含有雪旺细胞和成纤维细胞在多层辅助结构成熟过程中产生的分子。沉积到细胞外基质中的这些分子能够影响未成熟细胞对多层辅助结构的再分化。
