Kedziora-Kornatowska K Z, Luciak M, Paszkowski J
Department of Internal Diseases, Military Medical University, Lodz, Poland.
IUBMB Life. 2000 Apr;49(4):303-7. doi: 10.1080/15216540050033177.
Effects of the angiotensin convertase inhibitors captopril (CAP) and enalapril (ENA) on the malondialdehyde (MDA) content and the activities of superoxide dismutase (SOD) and catalase in the kidneys of rats with streptozotocin-induced diabetes were studied. Induction of diabetes resulted in an increase of MDA concentration and progressive decreases of SOD and catalase activities after 6 and 12 weeks. CAP and ENA administration did not affect body weight changes or blood glucose and HbA1c contents in diabetic rats but decreased albuminuria and kidney weight increase, attenuated lipid peroxidation, and prevented the decreases in SOD and catalase activities. These results confirm the oxidative stress in streptozotocin-induced experimental diabetes and point to the beneficial antioxidant effects of angiotensin convertase inhibitors.
研究了血管紧张素转换酶抑制剂卡托普利（CAP）和依那普利（ENA）对链脲佐菌素诱导的糖尿病大鼠肾脏中丙二醛（MDA）含量以及超氧化物歧化酶（SOD）和过氧化氢酶活性的影响。糖尿病的诱导导致6周和12周后MDA浓度升高以及SOD和过氧化氢酶活性逐渐降低。给予CAP和ENA对糖尿病大鼠的体重变化、血糖和糖化血红蛋白含量没有影响，但减少了蛋白尿和肾脏重量增加，减轻了脂质过氧化，并防止了SOD和过氧化氢酶活性的降低。这些结果证实了链脲佐菌素诱导的实验性糖尿病中的氧化应激，并表明血管紧张素转换酶抑制剂具有有益的抗氧化作用。
